Association of Serum Myeloperoxidase and Lipid Levels With Coronary Artery Lesion Severity and Major Adverse Cardiovascular Events in Patients With Acute Coronary Syndrome

• Published in: Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 56; no. 3; p. 804
• Main Authors: Li, Yulong, Li, Xiang
• Format: Journal Article
• Language: Chinese
• Published: China 20.05.2025
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - complications; Acute Coronary Syndrome - pathology; Aged; Angina, Unstable - blood; Coronary Vessels - pathology; Female; Humans; Lipids - blood; Male; Middle Aged; Non-ST Elevated Myocardial Infarction - blood; Peroxidase - blood; ROC Curve; Severity of Illness Index; Myeloperoxidase; Acute coronary syndrome; Blood lipid; Severity of coronary artery lesion; Major adverse cardiovascular event
• ISSN: 1672-173X
• DOI: 10.12182/20250560606

This study aims to investigate the relationship of serum myeloperoxidase (MPO) and blood lipid levels with the severity of coronary artery lesions and major adverse cardiovascular event (MACE) in patients with acute coronary syndrome (ACS). From May 2023 to January 2025, 216 ACS patients admitted to Yanbian University Hospital were enrolled as the study subjects. According to the disease types, they were divided into unstable angina pectoris (UAP group, = 69), ST elevation myocardial infarction (STEMI group, = 101), and non-ST elevation myocardial infarction (NSTEMI group, = 46) groups. Additionally, 94 patients with other diseases were selected as controls (control group, = 94). The serum MPO and blood lipid levels of the four groups were compared, and their relationships with the severity of coronary artery lesions in ACS patients were analyzed. ACS patients were further divided into MACE and non-MACE groups based on whether MACE occurred, and their serum MPO and blood lipid levels were compared. The receiv