The effectiveness of terazosin, an alpha1-blocker, on bladder neck obstruction as assessed by urodynamic hydraulic energy

• Published in: BJU international Vol. 85; no. 3; p. 249
• Main Authors: Yamanishi, T, Yasuda, K, Sakakibara, R, Hattori, T, Tojo, M
• Format: Journal Article
• Language: English
• Published: England 01.02.2000
• Subjects: Adrenergic alpha-Antagonists - therapeutic use; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Prazosin - analogs & derivatives; Prazosin - therapeutic use; Urinary Bladder Neck Obstruction - drug therapy; Urinary Bladder Neck Obstruction - physiopathology; Urodynamics
• ISSN: 1464-4096
• DOI: 10.1046/j.1464-410x.2000.00418.x

To investigate the effectiveness of terazosin, an alpha1-adrenoceptor blocking agent, on bladder neck obstruction (BNO), by assessing the urodynamic hydraulic energy profile. Patients, subjects and methods The study included 17 men (mean age 60.1 years, range 24-84), comprising 11 patients with BNO (mean age 66.5 years) and six normal volunteers (mean age 48.1 years). A five-transducer microtip catheter was used to measure the pressure in the bladder and at the bladder neck, and in the membranous and bulbous urethra during voiding. All the subjects then received terazosin, 1 mg/day orally for 2 weeks, and were re-assessed. The bladder neck diameter at maximum flow significantly (P < 0.02) increased in the 11 patients with BNO after treatment with terazosin. The relative hydraulic energy profiles before terazosin treatment showed the greatest hydraulic energy loss between the membranous and the bulbous urethra in the normal subjects, and between the bladder neck and the membranous urethra in the men with BNO. After terazosin treatment, the greatest energy loss was between the membranous and the bulbous urethra in men with BNO, similar to that in the normal controls, i.e. the whole profile of relative hydraulic energy became normal. Terazosin was effective in opening the bladder neck and improving the hydraulic energy profile in men with BNO.