Multilevel regulation of tyrosine hydroxylase. II. Transcriptional regulation

The tyrosine hydroxylase gene is subject to very precise regulation which aim is to adjust the level of the catecholamines to current stimuli disturbing the homeostasis. The fine tuning of the TH gene activity is realized by the "cross-talk" between the complexes of transcriptional factors...

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Bibliographic Details
Published inPostȩpy higieny i medycyny doświadczalnej Vol. 56; no. 5; p. 671
Main Authors Lenartowski, Robert, Goc, Anna
Format Journal Article
LanguagePolish
Published Poland 2002
Subjects
Catecholamines - metabolism
CpG Islands - physiology
E-Box Elements - physiology
Homeostasis - physiology
Humans
Methylation
Transcription Factor AP-1 - genetics
Transcription Factor AP-1 - metabolism
Transcription Factors - metabolism
Transcription, Genetic - physiology
Tyrosine 3-Monooxygenase - genetics
Tyrosine 3-Monooxygenase - metabolism
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ISSN0032-5449

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Summary:The tyrosine hydroxylase gene is subject to very precise regulation which aim is to adjust the level of the catecholamines to current stimuli disturbing the homeostasis. The fine tuning of the TH gene activity is realized by the "cross-talk" between the complexes of transcriptional factors with their appropriate regulatory sequences. The transcriptional aspect of that regulation has been reviewed emphasizing the rule of the regulatory sequences in determining cell, tissue and developmental specificity of the TH gene activity.
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SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0032-5449