Schizophrenia: elevated mRNA for calcium-calmodulin-dependent protein kinase IIbeta in frontal cortex

Because amphetamine releases two to three times more dopamine in schizophrenia patients than in control subjects, and because calcium-calmodulin-dependent protein kinase II has a key role in the enhanced action of amphetamine-induced dopamine release in rats, the synaptic content of calcium-calmodul...

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Bibliographic Details
Published inBrain research. Molecular brain research. Vol. 82; no. 1-2; p. 95
Main Authors Novak, G, Seeman, P, Tallerico, T
Format Journal Article
LanguageEnglish
Published Netherlands 20.10.2000
Subjects
Adult
Aged
Aged, 80 and over
Base Sequence
Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
Cyclic AMP-Dependent Protein Kinases - genetics
Female
Frontal Lobe - metabolism
Gene Expression Regulation, Enzymologic
Humans
Male
Molecular Sequence Data
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Schizophrenia - enzymology
Schizophrenia - genetics
Transcription, Genetic
Online AccessGet full text
ISSN0169-328X
DOI10.1016/s0169-328x(00)00188-1

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Summary:Because amphetamine releases two to three times more dopamine in schizophrenia patients than in control subjects, and because calcium-calmodulin-dependent protein kinase II has a key role in the enhanced action of amphetamine-induced dopamine release in rats, the synaptic content of calcium-calmodulin-dependent protein kinase IIbeta mRNA was measured (by quantitative competitive RT-PCR; reverse transcriptase-polymerase chain reaction) in seven frontal cerebral cortices of post-mortem brains from patients who had schizophrenia and in seven control tissues. The results indicate that the mRNA of this kinase is elevated in the schizophrenia frontal cortex.
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ISSN:0169-328X
DOI:10.1016/s0169-328x(00)00188-1