First observations on the main plasma parameters of oxidative stress in homozygous sickle cell disease

• Published in: Bulletin de la Societe de pathologie exotique (1990) Vol. 85; no. 2; p. 174
• Main Authors: Sess, D, Carbonneau, M A, Thomas, M J, Dumon, M F, Peuchant, E, Perromat, A, Le Bras, M, Clerc, M
• Format: Journal Article
• Language: French
• Published: France 1992
• Subjects: Adolescent; Adult; Child; Child, Preschool; Homozygote; Humans; Male; Malondialdehyde - blood; Middle Aged; Oxidation-Reduction; Sickle Cell Trait - blood; Sickle Cell Trait - genetics
• ISSN: 0037-9085

The present study report 7 cases of sickle homozygous disease which have been analysed using markers of the oxidative-stress, 26 african male subjects were studied: 7 Hb SS subjects (age: m = 20) and 19 control subjects (Hb AA, age: m = 40). Plasma concentrations of F-MDA, T-MDA, TBARS, alpha tocopherol, retinol and beta carotene were measured. Plasma MDA and TBARS mean levels increased in sickle homozygous patients more than in controls. However, only TBARS mean concentrations were significantly increased between patients and controls: TBARS: 4.14 +/- 1.49 nMol/ml for Hb SS versus 2.10 +/- 1.21 nMol/ml for Hb AA (P less than 0.005). Vitamin A and vitamin E concentrations were significantly lower in Hb SS than in Hb AA. Beta carotene was significantly increased in patients vs controls. The significant increase of TBARS explains the great importance of the oxidative damage, whereas the significant decrease of vitamins A and E, may contribute, at least for a part, to maintain the autoxidation process or reveals its intensity in these patients.