Risk of arsenic-related skin lesions in Bangladeshi villages at relatively low exposure : a report from Gonoshasthaya Kendra

• Published in: Bulletin of the World Health Organization Vol. 85; no. 9; pp. 668 - 673
• Main Authors: MCDONALD, Corbett, HOQUE, Rezaul, HUDA, Nazmul, CHERRY, Nicola
• Format: Journal Article
• Language: English
• Published: Genève Organisation mondiale de la santé 01.09.2007; World Health Organization
• Subjects: Adolescent; Adult; Age; Aged; Arsenic; Arsenic - adverse effects; Arsenic - analysis; Arsenic Poisoning - complications; Bangladesh; Bangladesh - epidemiology; Biological and medical sciences; Case studies; Child; Child, Preschool; Dermatology; Drinking water; Dyskeratosis; Environmental Exposure - adverse effects; Environmental Exposure - analysis; Exposure; Female; Health Surveys; Humans; Infant; Keratosis - chemically induced; Keratosis - epidemiology; Lesions; Male; Medical sciences; Middle Aged; NGOs; Nongovernmental organizations; Paramedics; Polls & surveys; Population; Prevalence; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Referents; Regression analysis; Risk Assessment; Risk factors; Rural Population; Skin diseases; Skin disorders; Surveillance; Surveillance systems; Towns; Villages; Water quality; Wells; Women; Womens health; Asia; Bangladesh; Human; Water; Dyskeratosis; Skin disease; Prevalence; Arsenic; Toxicity; Hyperkeratosis; Concentration; Case control study; Knowledge; Nongovernmental organization; Prevention; Survey; Surveillance; Risk factor; Water quality; Feasibility; Woman; Age; WHO
• ISSN: 0042-9686; 1564-0604
• DOI: 10.2471/BLT.06.036764

Arsenic concentrations in 25% of tube wells in Bangladesh exceed 50 microg/L, a level known to be hazardous. Levels in individual wells vary widely. We gathered data on arsenic exposure levels and skin lesion prevalence to address the lack of knowledge about risks where the average arsenic concentrations was lower. The nongovernmental organization Gonoshasthaya Kendra did three related studies of keratotic skin lesions since 2004: (1) an ecological prevalence survey among 13 705 women aged > 18 in a random sample of 53 villages; (2) a case-control study of 176 cases and age- and village-matched referents; and (3) a prevalence survey of the entire population of 11,670 in two additional villages. We calculated prevalence as a function of average arsenic concentrations as reported in the National Hydrochemical Survey, and measured arsenic concentrations in wells used by subjects in the case-control study. The prevalence of skin lesions was 0.37% in people exposed to arsenic concentrations below 5 microg/L, 0.63% at 6-50 microg/L, and 6.84% at 81 microg/L. In the case-control analysis, relative risk of skin lesions increased threefold at concentrations above 50 microg/L (P < 0.05). Little serious skin disease is likely to occur if the arsenic concentration in drinking water is kept below 50 microg/L, but ensuring this water quality will require systematic surveillance and reliable testing of all wells, which may be impractical. More research is needed on feasible prevention of toxic effects from arsenic exposure in Bangladesh.