Characterization of γδ T cell subsets in organ transplantation

Summary γδ T cells are innate‐type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood γδ T cells (Vδ1 and Vδ2) in operationally tolerant liver transplant recipients. Based on this,...

Full description

Saved in:
Bibliographic Details
Published inTransplant international Vol. 23; no. 10; pp. 1045 - 1055
Main Authors Puig‐Pey, Isabel, Bohne, Felix, Benítez, Carlos, López, Marta, Martínez‐Llordella, Marc, Oppenheimer, Federico, Lozano, Juan José, González‐Abraldes, Juan, Tisone, Giuseppe, Rimola, Antoni, Sánchez‐Fueyo, Alberto
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2010
Subjects
Online AccessGet full text
ISSN0934-0874
1432-2277
1432-2277
DOI10.1111/j.1432-2277.2010.01095.x

Cover

More Information
Summary:Summary γδ T cells are innate‐type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood γδ T cells (Vδ1 and Vδ2) in operationally tolerant liver transplant recipients. Based on this, γδ T cells subset quantification was proposed as a biomarker of immunologic risk in liver transplantation. The specific characteristics of γδ T cell subsets in transplantation remain however unknown. We have investigated here the phenotype, repertoire and functional properties of γδ T cell subsets in a large population of allograft recipients. Our results indicate that alterations in the γδ T cell compartment are not restricted to tolerant liver recipients. In fact, most immunosuppressed liver and kidney recipients also display an enlarged peripheral blood γδ T cell pool mainly resulting from an expansion of Vδ1 T cells exhibiting an oligoclonal repertoire and different phenotypic and cytokine production traits than Vδ2 T cells. We propose that persistent viral infections are likely to contribute to these alterations. Our data provide novel insight in the biology of γδ T cells and a rationale for exploring these lymphocytes in more depth into the pathogenesis of viral infections in transplantation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0934-0874
1432-2277
1432-2277
DOI:10.1111/j.1432-2277.2010.01095.x