Stochastic anomaly detection in eye-tracking data for quantification of motor symptoms in Parkinson's disease

• Published in: Advances in experimental medicine and biology Vol. 823; p. 63
• Main Authors: Jansson, Daniel, Medvedev, Alexander, Axelson, Hans, Nyholm, Dag
• Format: Journal Article
• Language: English
• Published: United States 2015
• Subjects: Algorithms; Eye Movements - physiology; Humans; Models, Biological; Parkinson Disease - diagnosis; Parkinson Disease - physiopathology; Photic Stimulation; Pursuit, Smooth - physiology; Stochastic Processes
• ISSN: 0065-2598
• DOI: 10.1007/978-3-319-10984-8_4

Two methods for distinguishing between healthy controls and patients diagnosed with Parkinson's disease by means of recorded smooth pursuit eye movements are presented and evaluated. Both methods are based on the principles of stochastic anomaly detection and make use of orthogonal series approximation for probability distribution estimation. The first method relies on the identification of a Wiener model of the smooth pursuit system and attempts to find statistically significant differences between the estimated parameters in healthy controls and patients with Parkinson's disease. The second method applies the same statistical method to distinguish between the gaze trajectories of healthy and Parkinson subjects tracking visual stimuli. Both methods show promising results, where healthy controls and patients with Parkinson's disease are effectively separated in terms of the considered metric. The results are preliminary because of the small number of participating test subjects, but they are indicative of the potential of the presented methods as diagnosing or staging tools for Parkinson's disease.