Elemental‐Sulfur‐Enabled Divergent Synthesis of Disulfides, Diselenides, and Polythiophenes from β‐CF3‐1,3‐Enynes

• Published in: Angewandte Chemie International Edition Vol. 60; no. 2; pp. 881 - 888
• Main Authors: Jin, Shengnan, Li, Shi‐Jun, Ma, Xingxing, Su, Jianke, Chen, Haohua, Lan, Yu, Song, Qiuling
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 11.01.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: 1,3-enynes; Aromatic compounds; CF3 containing heteroaromatics; Chemical reactions; Chemistry; Chemistry, Multidisciplinary; diselenides; Disulfides; Divergence; Nitrogen dioxide; Physical Sciences; Polythiophene; Science & Technology; Selenides; Substrates; Sulfur; Synthesis; thienobenzothiophene (TBT); TRISULFUR RADICAL-ANION; POLYMERS; diselenides; thienobenzothiophene (TBT); CF3 containing heteroaromatics; FIELD-EFFECT TRANSISTORS; 1; disulfides; 3-enynes; FACILE SYNTHESIS; DITHIOLOPYRROLONES; BIOSYNTHESIS; UNSYMMETRICAL DISULFIDES; DERIVATIVES; PRECURSORS; DISULFANES
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.202009194

Divergent synthesis for precise constructions of cyclic unsymmetrical diaryl disulfides or diselenides and polythiophenes from CF3‐containing 1,3‐enynes and S8 was developed when the ortho group is F, Cl, Br, and NO2 on aromatic rings. Meanwhile, disulfides (diselenides) were also quickly constructed when the ortho group is H. These transformations undergo cascade thiophene construction/selective C3‐position thiolation process, featuring simple operations, divergent synthesis, broad substrate scope, readily available starting materials, and valuable products. A novel plausible radical annulation process was proposed and validated by DFT calculations for the first time. A series of derivatizations about the thiophene (TBT) and disulfides were also well‐represented. A divergent synthesis for construction of cyclic unsymmetrical diaryl disulfides, diselenides, and polythiophenes from CF3‐containing 1,3‐enynes (ortho=F, Cl, Br, NO2, S8) was developed. Disulfides (diselenides) were constructed under mild conditions for ortho=H. These transformations undergo a cascade thiophene construction/selective C3‐position thiolation process, with mild conditions, broad substrate scope, and good functional‐group tolerance.