Role of Microtubule-Associated Factors in HIF1α Nuclear Translocation

• Published in: Advances in experimental medicine and biology Vol. 1232; pp. 271 - 276
• Main Authors: Lee, Hyun Jik, Han, Ho Jae
• Format: Book Chapter Journal Article
• Language: English
• Published: Cham Springer International Publishing 2020
• Series: Advances in Experimental Medicine and Biology
• Subjects: Active Transport, Cell Nucleus - genetics; Bicaudal D homolog (BICD); Calcium; Cell Hypoxia - physiology; Cell Nucleus - metabolism; Factor inhibiting HIF (FIH); HIF1α co-activator; Humans; Hypoxia; Hypoxia-inducible factor 1 alpha (HIF1α); Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Microtubule; Microtubules - metabolism; Prolyl hydroxylase (PHD); Protein Transport - genetics; Stem cells; Factor inhibiting HIF (FIH); Bicaudal D homolog (BICD); Calcium; Stem cells; Prolyl hydroxylase (PHD); Hypoxia; HIF1α co-activator; Microtubule; Hypoxia-inducible factor 1 alpha (HIF1α)
• ISBN: 3030344592; 9783030344597
• ISSN: 0065-2598; 2214-8019
• DOI: 10.1007/978-3-030-34461-0_34

Adaptation to hypoxia is essential for regulating the survival and functions of hypoxic cells; it is mainly mediated by the hypoxia-inducible factor 1 (HIF1). The alpha subunit of HIF1 (HIF1α) is a well-known regulatory component of HIF1, which is tightly controlled by various types of HIF1α-regulating processes. Previous research has shown that microtubule-regulated HIF1α nuclear translocation is a key factor for HIF1 activation under hypoxia. In this review, we summarize experimental reports on the role of microtubule-associated factors, such as microtubule, dynein, and dynein adaptor protein, in nuclear translocation of HIF1α. Based upon scientific evidence, we propose a bicaudal D homolog (BICD) as a novel HIF1α translocation regulating factor. A deeper understanding of the mechanism of the action of regulatory factors in controlling HIF1α nuclear translocation will provide novel insights into cell biology under hypoxia.