Global Sensitivity Analysis for a Chronic Myelogenous Leukemia Model

The goal of this paper is to carry out a global sensitivity analysis applied to a mathematical model for chronic myelogenous leukemia (CML) dynamics with T cell interaction. The interaction mechanism between naïve T cells, effector T cells, and CML cancer cells in the body is modeled by a system of...

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Bibliographic Details
Published inNumerical Methods and Applications Vol. 11189; pp. 375 - 382
Main Author Dimitriu, Gabriel
Format Book Chapter
LanguageEnglish
Published Switzerland Springer International Publishing AG 2019
Springer International Publishing
SeriesLecture Notes in Computer Science
Online AccessGet full text
ISBN9783030106911
3030106918
ISSN0302-9743
1611-3349
DOI10.1007/978-3-030-10692-8_42

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Summary:The goal of this paper is to carry out a global sensitivity analysis applied to a mathematical model for chronic myelogenous leukemia (CML) dynamics with T cell interaction. The interaction mechanism between naïve T cells, effector T cells, and CML cancer cells in the body is modeled by a system of ordinary differential equations which defines rates of variation for the three cell populations. We explain how to globally analyse the sensitivity of this complex system by means of two graphical objects: the sensitivity heat map and the parameter sensitivity spectrum.
ISBN:9783030106911
3030106918
ISSN:0302-9743
1611-3349
DOI:10.1007/978-3-030-10692-8_42