A U-shaped relationship between ankle-brachial index and carotid intima-media thickness in a Chinese population of inner Mongolia

• Published in: International angiology Vol. 30; no. 5; pp. 451 - 457
• Main Authors: WANG, Y, LI, J, GUO, X, ZHAO, D, HU, D, WEI, Y, HOU, L, XU, Y, MA, Y
• Format: Journal Article
• Language: English
• Published: Torino Minerva Medica 01.10.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Asian Continental Ancestry Group - statistics & numerical data; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Carotid Arteries - diagnostic imaging; Carotid Artery Diseases - diagnosis; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - ethnology; Carotid Artery Diseases - physiopathology; Chi-Square Distribution; China - epidemiology; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Humans; Linear Models; Logistic Models; Male; Medical sciences; Middle Aged; Odds Ratio; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - diagnostic imaging; Peripheral Arterial Disease - ethnology; Peripheral Arterial Disease - physiopathology; Predictive Value of Tests; Prevalence; Risk Assessment; Risk Factors; Tunica Intima - diagnostic imaging; Tunica Media - diagnostic imaging; Ultrasonography; Young Adult; Carotid stenosis; Nervous system diseases; Prevalence; Ankle brachial index; Peripheral arterial disease; Cardiovascular disease; Artery; Risk factors; Cerebral disorder; Arterial disease; Vascular disease; Blood vessel; Carotid; Central nervous system disease; Risk factor; Occlusive arterial disease; Chinese; Circulatory system; Cerebrovascular disease
• ISSN: 0392-9590; 1827-1839; 1827-1839

The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases. Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampling. ABI and carotid-IMT were measured for each subject. Periphery arterial disease (PAD) was defined as an ABI≤0.9 in either leg. ABI values were divided into eight groups at every 0.05, and three carotid-IMT measures were compared among groups separately using analysis of variance (ANOVA) and multivariate linear regression analyses. The results indicated that the prevalence of PAD among 1236 participants was 1.9%. The average common carotid IMT was 0.70±0.21 mm, internal carotid IMT 0.77±0.24 mm, and carotid artery bifurcation IMT 0.78±0.25 mm. A U-shaped relationship was observed that the values of common carotid, carotid artery bifurcation, and internal carotid arteries IMT were decreased at first then increased as ABI values increased. The U-shaped relationship between ABI and three carotid-IMT measures were remained after adjusting for covariates. The data suggests that carotid IMT values are correlated with ABI values in a U-shaped curve. Increased carotid IMT is correlated with the high prevalence of PAD in population of Inner Mongolia in China.