Therapeutic Effects of Aqueous Extracts of Cerasus Avium Stem on Ethylene Glycol- Induced Kidney Calculi in Rats

• Published in: Urology journal Vol. 14; no. 4; p. 4024
• Main Authors: Azaryan, Ehsaneh, Malekaneh, Mohammad, Shemshadi Nejad, Maryam, Haghighi, Fatemeh
• Format: Journal Article
• Language: English
• Published: Iran Urology and Nephrology Research Center 02.07.2017
• Subjects: Animals; Calcium - blood; Calcium - urine; Calcium Oxalate - metabolism; Creatinine - blood; Creatinine - urine; Ethylene Glycol; Experiments; Kidney Calculi - drug therapy; Kidney Calculi - metabolism; Kidney Calculi - pathology; Kidney Calculi - prevention & control; Kidney stones; Magnesium - blood; Male; Phytotherapy; Plant Extracts - therapeutic use; Plant Stems; Potassium - blood; Prunus avium; Rats; Rats, Wistar; Rodents; Sodium - blood; Uric acid; Uric Acid - blood; Uric Acid - urine; Water
• ISSN: 1735-1308; 1735-546X; 1735-546X

To investigate the therapeutic effects of the aqueous extract of Cerasus Avium stem on kidney calculi. In this experimental study, forty-eight (48) male Wistar rats were randomly allocated into six (6) groups and were studied during a 30 day period. Group A served as normal control and Group B received 1% ethylene glycol in drinking water (EG group). C, D, E, and F Groups, received 1% ethylene glycol from day 1 and were used as prevention and treatment subjects. Rats in prevention groups of low dose (C) and high dose (D) extract, were gavaged with 200 and 400 mg/kg extract respectively from first day of the experiment and treatmentgroups of low dose (E) and high dose (F) extract, were gavaged with 200 and 400 mg/kg extract respectively from the 15th day of the experiment. On the 30th days of the experiment, serum level of magnesium and potassium decreased significantly in EG group compared with A,C,D,E and F groups (P < .05), while serum level of calcium, creatinine, uric acid, sodium and urine level of calcium, creatinine, uric acid, increased significantly in EG group compared with A,C,D,E and F groups (P < .05). In the prevention and treatment groups, the number of deposits decreased significantly compared with EG group on the 30th day (P < .05). Cerasus Avium stem has a therapeutic effect on calcium oxalate stones in rats with nephrolithiasis and reduces the number of calcium oxalate deposits.