Endocrine autoimmunity in patients with Latent Autoimmune Diabetes in Adults (LADA) — association with HLA genotype

• Published in: Endokrynologia Polska Vol. 67; no. 2; pp. 197 - 201
• Main Authors: Szepietowska, Barbara, Wawrusiewicz-Kurylonek, Natalia, Krętowski, Adam, Górska, Maria, Szelachowska, Małgorzata
• Format: Journal Article
• Language: English
• Published: Poland Wydawnictwo Via Medica 2016
• Subjects: Adult; Autoantibodies - blood; Autoantigens - immunology; Autoimmune diseases; Autoimmunity; Diabetes; Endocrine System Diseases - etiology; Endocrine System Diseases - immunology; Endocrine System Diseases - metabolism; Female; Genotype; Genotype & phenotype; HLA-DQ alpha-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; Iodide Peroxidase - immunology; Iron-Binding Proteins - immunology; Latent Autoimmune Diabetes in Adults - complications; Latent Autoimmune Diabetes in Adults - immunology; Latent Autoimmune Diabetes in Adults - metabolism; Male; Middle Aged; Steroid 21-Hydroxylase - immunology; Thyroglobulin - immunology; Thyroid gland
• ISSN: 0423-104X; 2299-8306
• DOI: 10.5603/EP.a2016.0017

Latent autoimmune diabetes in adults (LADA) is a slow-developing form of autoimmune diabetes, characterised by the presence of type 1 diabetes-associated autoantibody and presentation at diagnosis similar to patients with type 2 diabetes. The aim of this study was to determine the prevalence of auto-antibodies related to endocrine autoimmune diseases in patients with LADA and to assess their association with HLA genotype. We evaluated the presence of anti-thyroglobulin (ATG), anti-thyroid peroxidase (ATPO), anti-tissue transglutaminase IgA (ATTA), and anti 21 hydroxylase (A21H) in 70 patients with LADA, 69 with Type 2 diabetes, and in 50 healthy controls HLA genotype was assed in subpopulation of sluclied subjects. The presence of ATPO (28.6 vs. 10%); ATG (28.6 vs. 14%) was higher in patients with LADA in comparison to healthy controls and ATPO in comparison to patients with type 2 diabetes (38.6 vs. 17.4 %). In patients with LADA the presence of autoimmune thyroid autoantibodies was associated with newly diagnosed subclinical hypothyroidism; almost 7% of patients presented with high TSH. The presence of A21H (2.86 vs. 5.8 vs. 6.1%) and ATTA (2.86 vs. 4.3 vs. 6.0%) was not different between groups. Patients with high TSH level were positive for DQA1*0301 and DRB1*04 HLA genotype: DQB1*0201 and DQB1*02 were higher in patients positive for ATTA. Patients with LADA have higher prevalence of thyroid autoimmune diseases. In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.