Hydroxylation of progesterone by some Trichoderma species

Thirty-three isolates belonging to six species of the genus Trichoderma were tested for the ability to hydroxylate progesterone to 11alpha-, 11beta-, 11alpha,17alpha- and 6beta, 17alpha-derivatives, and epicortisol. T. aureoviride, T. harzianum, T. polysporum and T. pseudokoningii produced 11alpha-h...

Full description

Saved in:
Bibliographic Details
Published inFolia microbiologica Vol. 49; no. 3; pp. 285 - 290
Main Authors El-Kadi, I A, Mostafa, M Eman
Format Journal Article
LanguageEnglish
Published United States 2004
Subjects
Biotransformation
Hydroxylation
Progesterone - chemistry
Progesterone - metabolism
Trichoderma
Trichoderma - growth & development
Trichoderma - isolation & purification
Trichoderma - metabolism
Online AccessGet full text
ISSN0015-5632
DOI10.1007/BF02931044

Cover

More Information
Summary:Thirty-three isolates belonging to six species of the genus Trichoderma were tested for the ability to hydroxylate progesterone to 11alpha-, 11beta-, 11alpha,17alpha- and 6beta, 17alpha-derivatives, and epicortisol. T. aureoviride, T. harzianum, T. polysporum and T. pseudokoningii produced 11alpha-hydroxyprogesterone. T. harzianum and T. hamatum can form only the 11beta-isomer. T. koningii and T. hamatum produced 11alpha-, 11beta-, 11alpha,17alpha- and 6beta,11alpha-hydroxy derivatives. 11alpha, 11beta, 6beta,11alpha- and 11alpha,17alpha-hydroxyprogesterones and epicortisol are produced by T. aureoviride and T. pseudokoningii. Cortisol was produced only when the medium was fortified by 10 g/L peptone. This is the first record of conversion of progesterone to mono-, di- and trihydroxyprogesterones by these Trichoderma species.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0015-5632
DOI:10.1007/BF02931044