CC16 Binding to α4β1 Integrin Protects against Mycoplasma pneumoniae Infection

Johnson et al. discusses the role of CC16 binding to α4β1 integrin to protect against Mycoplasma pneumoniae infection. A Mycoplasma pneumoniae mouse model and a fluorescent cellular adhesion assay were used to determine the impact of the LVD site regarding CC16 function during live infection and on...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 203; no. 11; pp. 1410 - 1418
Main Authors L Johnson, Michael D, Younis, Usir S, Menghani, Sanjay V, Addison, Kenneth J, Whalen, Michael, Pilon, Aprile L, Cress, Anne E, Polverino, Francesca, Romanoski, Casey E, Kraft, Monica, Martinez, Fernando D, Guerra, Stefano, Ledford, Julie G
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.06.2021
Subjects
Bacterial infections
Cells
Disease prevention
Inflammation
Lung diseases
Original
Pathogenesis
Online AccessGet full text
ISSN1073-449X
1535-4970
1535-4970
DOI10.1164/rccm.202006-2576OC

Cover

More Information
Summary:Johnson et al. discusses the role of CC16 binding to α4β1 integrin to protect against Mycoplasma pneumoniae infection. A Mycoplasma pneumoniae mouse model and a fluorescent cellular adhesion assay were used to determine the impact of the LVD site regarding CC16 function during live infection and on cellular adhesion during inflammatory conditions. They discovered a novel receptor for CC16, VLA-4, which has important mechanistic implications for the role of CC16 in circulation as well as in the lung compartment.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.202006-2576OC