The Value of High-Sensitivity C-reactive Protein in Evaluating Myocardial Damage and the Prognosis in Children with Mycoplasmal Pneumonia

• Published in: Annals of clinical and laboratory science Vol. 51; no. 5; p. 721
• Main Authors: Lai, Meimei, Ai, Tao, Yang, Shuzhe, Wei, Yongqiong, Deng, Yao, Yu, Xia, Zhang, Lei
• Format: Journal Article
• Language: English
• Published: United States 01.09.2021
• Subjects: Anti-Bacterial Agents - therapeutic use; Biomarkers - analysis; C-Reactive Protein - analysis; Case-Control Studies; Child; Child, Preschool; Creatine Kinase, MB Form - blood; Electrocardiography; Erythromycin - therapeutic use; Female; Humans; Male; Myocardium - pathology; Pneumonia, Mycoplasma - blood; Pneumonia, Mycoplasma - drug therapy; Pneumonia, Mycoplasma - physiopathology; Prognosis; Sensitivity and Specificity; mycoplasmal pneumonia; myocardial damage; high-sensitivity C-reactive protein; children
• ISSN: 1550-8080; 1550-8080

To investigate the value of high-sensitivity C-reactive protein (hs-CRP) in evaluating the myocardial damage and prognosis in children with mycoplasmal pneumonia. A total of 150 children with mycoplasmal pneumonia were selected. According to their serum creatine kinase isoenzyme (CK-MB) level, they were divided into 72 cases of the myocardial damage group and 78 cases of the non-myocardial damage group. Eighty healthy children undergoing physical examination were selected as the control group. The electrocardiography results and serum CK-MB and hs-CRP levels were compared among the subjects. The correlations among the above indexes were analyzed. The levels of hs-CRP and CK-MB in the myocardial damage group were significantly higher than those in the nonmyocardial damage group and control group, respectively ( <0.05). The rates of abnormal hs-CRP and abnormal electrocardiogram in the myocardial damage group were significantly higher than those in the non-myocardial damage group, respectively ( <0.05). In the 150 children with mycoplasmal pneumonia, the serum hs-CRP and CK-MB levels were positively correlated ( <0.001), and the abnormal hs-CRP rate was positively correlated with the abnormal electrocardiogram rate ( <0.001). In the myocardial damage group, the serum levels of hs-CRP and CK-MB after treatment were significantly lower than those before treatment, respectively ( <0.05). After treatment, each index in the myocardial damage group had no significant difference with those in the control group ( >0.05). hs-CRP may be an important index for evaluating the myocardial damage and prognosis in children with mycoplasmal pneumonia. The combination of hs-CRP and CK-MB detection has obvious guiding significance for the monitoring and treatment of mycoplasmal pneumonia complicated by myocardial damage.