IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells

• Published in: Nature immunology Vol. 16; no. 2; p. 161
• Main Authors: Huang, Yuefeng, Guo, Liying, Qiu, Jin, Chen, Xi, Hu-Li, Jane, Siebenlist, Ulrich, Williamson, Peter R, Urban, Jr, Joseph F, Paul, William E
• Format: Journal Article
• Language: English
• Published: United States 01.02.2015
• Subjects: Animals; Animals, Genetically Modified; Candida albicans - immunology; Candidiasis - immunology; Cell Lineage; Gene Deletion; Inflammation - immunology; Interleukin-17 - metabolism; Lectins, C-Type; Leukocytes - immunology; Lung - immunology; Lung - pathology; Lymphocytes - cytology; Lymphocytes - immunology; Mice; Nippostrongylus - immunology; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Receptors, Interleukin-7 - metabolism; Strongylida Infections - immunology
• ISSN: 1529-2916; 1529-2916
• DOI: 10.1038/ni.3078

Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to the expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing ability and provided partial protection against Candida albicans. We propose that iILC2 cells are transient progenitors of ILCs mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi.