The role of inflammation in patients with intraductal mucinous neoplasm of the pancreas and in those with pancreatic adenocarcinoma

• Published in: Anticancer research Vol. 30; no. 9; p. 3801
• Main Authors: Pezzilli, Raffaele, Corsi, Massimiliano M, Barassi, Alessandra, Morselli-Labate, Antonio M, Dogliotti, Giada, Casadei, Riccardo, Corinaldesi, Roberto, D'Eril, Gianvico Melzi
• Format: Journal Article
• Language: English
• Published: Greece 01.09.2010
• Subjects: Adenocarcinoma, Mucinous - immunology; Adenocarcinoma, Mucinous - metabolism; Adenocarcinoma, Mucinous - pathology; Aged; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - blood; Male; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology
• ISSN: 1791-7530; 1791-7530

There are very few data regarding inflammation in patients with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. To evaluate the circulating concentrations of placental growth factor (PlGF), transforming growth factor-alpha (TGF-α), transforming growth factor-beta1 (TGF-β1), tumour necrosis factor receptor 1 (TNF-R1) and matrix metalloproteinase-2 (MMP-2) in patients with IPMNs and in those with pancreatic adenocarcinomas. Sixty-nine patients were enrolled: 23 (33.3%) had IPMNs and 46 (66.7%) had histologically confirmed pancreatic adenocarcinomas. Thirteen healthy subjects were also studied. PlGF, TGF-α, TGF-β1, TNF-R1 and MMP-2 were determined using commercially available kits. TNF-R1 (p=0.003) was the only protein significantly different among the three groups. Serum TNF-R1 was elevated in patients with IPMNs and in those with pancreatic adenocarcinomas, suggesting a high apoptotic activity in both groups of patients studied.