Aging and sodium homeostasis

Deterioration of glomerular filtration rate appears to be progressive throughout life whereas sodium intake tends to remain constant. The influence of aging may be amplified by intrinsic renal disease, unilateral nephrectomy or renovascular abnormalities. Changes in the tubular reabsorption of sodiu...

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Bibliographic Details
Published inKidney international. Supplement Vol. 37; p. S107
Main Authors Mimran, A, Ribstein, J, Jover, B
Format Journal Article
LanguageEnglish
Published United States 01.06.1992
Subjects
Aging - physiology
Animals
Blood Pressure - physiology
Homeostasis - physiology
Humans
Kidney - physiology
Natriuresis - physiology
Rats
Renin-Angiotensin System - physiology
Sodium - metabolism
Sodium, Dietary - administration & dosage
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ISSN0098-6577

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Summary:Deterioration of glomerular filtration rate appears to be progressive throughout life whereas sodium intake tends to remain constant. The influence of aging may be amplified by intrinsic renal disease, unilateral nephrectomy or renovascular abnormalities. Changes in the tubular reabsorption of sodium will allow the excretory capacity of the kidney to adjust to fluctuations in normal sodium intake. However, restriction of dietary sodium may be associated with a sluggish renal response; a sodium wasting state that could lead to significant deterioration in renal function and orthostatic hypotension, may occur. Conversely, increasing dietary sodium in older subjects may result in a rise in arterial pressure more often than in younger subjects. Dietary sodium restriction should be carefully controlled in elderly subjects.
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ISSN:0098-6577