Pulmonary Tumor Thrombotic Microangiopathy: A Rapidly Progressive Form of Pulmonary Hypertension in Cancer Patients

Pulmonary hypertension in patients with advanced solid organ tumors may be secondary to a rare diagnosis of pulmonary tumor thrombotic microangiopathy. Current literature is limited to case reports, and there is no consensus on diagnosis and management. This case highlights the importance of a high...

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Published inJACC. Case reports Vol. 30; no. 5; p. 103194
Main Authors Ali, Hyeon-Ju, Cui, Shengjie, Sahay, Sandeep, Grosu, Horiana B, Riben, Michael W, Deswal, Anita, Mouhayar, Elie, Iliescu, Cezar, Ali, Abdelrahman, Faiz, Saadia A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 05.03.2025
Subjects
Cardio-Oncology
cancer
right ventricular failure
metastatic adenocarcinoma
pulmonary hypertension
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ISSN2666-0849
2666-0849
DOI10.1016/j.jaccas.2024.103194

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Summary:Pulmonary hypertension in patients with advanced solid organ tumors may be secondary to a rare diagnosis of pulmonary tumor thrombotic microangiopathy. Current literature is limited to case reports, and there is no consensus on diagnosis and management. This case highlights the importance of a high degree of clinical suspicion and the role of additional work-up for pulmonary tumor thrombotic microangiopathy including fludeoxyglucose-19-positron emission tomography and cytology of pulmonary artery blood sample at the time of right-sided heart catheterization. Future studies are needed to better understand the role of pulmonary vasodilators and targeted therapies, such as platelet-derived growth factor inhibitors, and their impact on the clinical outcomes for patients with poor prognosis secondary to their cancers.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:2666-0849
2666-0849
DOI:10.1016/j.jaccas.2024.103194