The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in korean women : A case control study

• Published in: Gynecologic and obstetric investigation Vol. 64; no. 2; pp. 84 - 88
• Main Authors: JO, Hoenil, KANG, Sokbom, SUNG IL KIM, JAE WEON KIM, NOH HYUN PARK, YONG SANG SONG, PARK, Sang-Yoon, SOON BEOM KANG, HYO PYO LEE
• Format: Journal Article
• Language: English
• Published: Basel Karger 01.08.2007; S. Karger AG
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Case-Control Studies; Chi-Square Distribution; DNA-Binding Proteins - genetics; Endometrial Neoplasms - epidemiology; Endometrial Neoplasms - genetics; Endometrial Neoplasms - pathology; Endonucleases - genetics; Female; Female genital diseases; Genotype; Gynecology. Andrology. Obstetrics; Humans; Korea - epidemiology; Logistic Models; Medical sciences; Middle Aged; Neoplasms, Glandular and Epithelial - epidemiology; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - pathology; Odds Ratio; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Polymorphism, Genetic; Prospective Studies; Risk Factors; Tumors; Asia; Korea; Endometrial Cancer; Andrology; Endometrium cancer; Ovary carcinoma; Genetic variability; Ovary cancer; Risk; Excision repair cross-complementing group 1; Case control study; Epidemiology; DNA repair; DNA repair gene; Repair gene; Ovarian Cancer; Female genital system; Uterine diseases; Adult; Female; Woman; Endometrium; Human; Excision; Gynecology; Genotype; Malignant tumor; Obstetrics; Female genital diseases; Ovarian diseases; DNA; Risk factor; Polymorphism
• ISSN: 0378-7346; 1423-002X; 1423-002X
• DOI: 10.1159/000100008

Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis. We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects. We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively). Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women.