Assessing FBA Optimal States in the Feasible Flux Phenotypic Space

Optimal growth solutions can be confronted with the whole set of feasible flux phenotypes (FFP), which provides a reference map that helps to assess the likelihood of optimal and high-growth states and their extent of conformity with experimental results. In addition, FFP maps are able to uncover me...

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Bibliographic Details
Published inA Network-Based Approach to Cell Metabolism pp. 115 - 129
Main Author Güell, Oriol
Format Book Chapter
LanguageEnglish
Published Switzerland Springer International Publishing AG 2017
Springer International Publishing
SeriesSpringer Theses
Subjects
BIOCHEMICAL ENGINEERING
Carbon Source Uptake Rate
Feasible Flux
High-growth States
Life sciences: general issues
Metabolic Behavior
Physical chemistry
Succinate Uptake
Online AccessGet full text
ISBN9783319639994
3319639994
ISSN2190-5053
2190-5061
DOI10.1007/978-3-319-64000-6_6

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Summary:Optimal growth solutions can be confronted with the whole set of feasible flux phenotypes (FFP), which provides a reference map that helps to assess the likelihood of optimal and high-growth states and their extent of conformity with experimental results. In addition, FFP maps are able to uncover metabolic behaviours that are unreachable using models based on optimality principles. The information content of the full FFP space of metabolic states provides with an entire map to explore and evaluate metabolic behaviour and capabilities, opening new avenues for biotechnological and biomedical applications.
ISBN:9783319639994
3319639994
ISSN:2190-5053
2190-5061
DOI:10.1007/978-3-319-64000-6_6