Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review

Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, i...

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Published inJournal of the American College of Cardiology Vol. 74; no. 14; p. 1823
Main Authors Sarnak, Mark J, Amann, Kerstin, Bangalore, Sripal, Cavalcante, João L, Charytan, David M, Craig, Jonathan C, Gill, John S, Hlatky, Mark A, Jardine, Alan G, Landmesser, Ulf, Newby, L Kristin, Herzog, Charles A, Cheung, Michael, Wheeler, David C, Winkelmayer, Wolfgang C, Marwick, Thomas H
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 08.10.2019
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ISSN0735-1097
1558-3597
1558-3597
DOI10.1016/j.jacc.2019.08.1017

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Summary:Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-stage kidney disease not only increase the risk of CAD, but they also modify its clinical presentation and cardinal symptoms. Management of CAD is complicated in CKD patients, due to their likelihood of comorbid conditions and potential for side effects during interventions. This summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD and CKD (including end-stage kidney disease and transplant recipients) seeks to improve understanding of the epidemiology, pathophysiology, diagnosis, and treatment of CAD in CKD and to identify knowledge gaps, areas of controversy, and priorities for research.
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ISSN:0735-1097
1558-3597
1558-3597
DOI:10.1016/j.jacc.2019.08.1017