AGEs BlockerTM (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice

• Published in: Preventive nutrition and food science Vol. 28; no. 2; pp. 134 - 140
• Main Authors: Jin Hee Yoo, Je Sung Lee, Ji Hwan Jang, Jae In Jung, Eun Ji Kim, Su-Young Choi
• Format: Journal Article
• Language: English
• Published: 한국식품영양과학회 01.06.2023
• Subjects: 식품과학; skin aging; N-carboxymethyllysine; antiglycation; receptor for advanced glycation end products; advanced glycation end products
• ISSN: 2287-1098; 2287-8602

Glycation is a cause of skin aging. This study investigated in a glycation-induced skin aging mouse model the effects on skin and mechanism of action of AGEs BlockerTM (AB), which contains goji berry, fig, and Korean mint mixed extract. This study sought to demonstrate the antiglycation effect of streptozotocin, thereby improving skin aging, by measuring advanced glycation end products (AGEs) and various skin parameters, including collagen; matrix metalloproteinases (MMPs); inflammatory cytokines; activities of oxidative enzymes; and skin wrinkles, elasticity, and hydration. This study found that skin wrinkles, elasticity, and hydration improved with AB. Particularly, the oral administration of AB suppressed AGEs, receptors of AGEs, and carboxymethyl lysine in blood and skin tissue. In addition, AB increased the activities of antioxidative enzymes, reduced inflammatory cytokines, suppressed MMP-9 expression, and increased the contents of collagen and hyaluronic acid, ultimately suppressing skin wrinkles and increasing skin elasticity and hydration. Therefore, AB can inhibit skin aging through its antiglycation effect and is thus considered a good ingredient for skin care products. KCI Citation Count: 1