RAW 264.7 cell의 염증반응에 대한 散熱飮子의 항염증 효과

Sanyeoleumja (SY) is the traditional Korean medicinal prescription for the treatment of inflammatory diseases of eyes. In this study, the anti-inflammatory effects of SY water extract were investigated. To measure the anti-inflammatory effects of SY, we examined the productions of inflammatory facto...

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Bibliographic Details
Published in동의생리병리학회지 Vol. 34; no. 1; pp. 7 - 13
Main Author 김태연(Tae Yeon Kim)
Format Journal Article
LanguageKorean
Published 한의병리학회 01.02.2020
Subjects
한의학
NO
Sanyeoleumja (SY)
Anti-inflammatory
Inflammatory factor
PGE
Online AccessGet full text
ISSN1738-7698
2288-2529
DOI10.15188/kjopp.2020.02.34.1.7

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Summary:Sanyeoleumja (SY) is the traditional Korean medicinal prescription for the treatment of inflammatory diseases of eyes. In this study, the anti-inflammatory effects of SY water extract were investigated. To measure the anti-inflammatory effects of SY, we examined the productions of inflammatory factor including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), interleukin-1β (IL-1β) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. SY inhibited NO and PGE2 production in a dose dependent manner and decreased the protein and mRNA expression of iNOS and COX-2. Also, SY decreased the mRNA expression of interleukin-6 (IL-6) and interleukin-1β (IL-1β). In conclusion, SY downregulated LPS-induced inflammatory factor productions, which could be a clinical basis for inflammatory diseases. KCI Citation Count: 0
Bibliography:https://kmpath.jams.or.kr
ISSN:1738-7698
2288-2529
DOI:10.15188/kjopp.2020.02.34.1.7