면역억제능을 보유한 地楡의 인슐린 분비능 연구

• Published in: 동의생리병리학회지 Vol. 28; no. 5; pp. 499 - 505
• Main Authors: 황석연(Seock Yeon Hwang), 김명현(Myung Hyun Kim), 강정수(Jung Soo Kang), 김병수(Byoung Soo Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.10.2014
• Subjects: 한의학; Sanguisorba officinalis; HNF-4α; immunosuppressor; insulin secretion
• ISSN: 1738-7698; 2288-2529
• DOI: 10.15188/kjopp.2014.10.28.5.499

Immunosuppressors cyclosporine A(CsA) and tacrolimus(FK506), the primary cellular target of which is calcineurin/nuclear factor of activated T cells(NFAT) signalling pathways, decrease beta-cell insulin content and mRNA expression. The posttransplantation diabetes mellitus(PTDM) is a frequent complication in immunosuppressive therapy. The present study was to examine the effect of a crude water extracts of medicinal herbs such as Sanguisorba officinalis(SOE) on the immunosuppressive activity with lymphocyte and insulin secretion in insulinoma cell lines with RIN-5mF. It was found that SOE treatment had effect of immunosuppressor on lymphocytes and also significantly increased insulin secretion in RIN-5mF compared to other agents. we might suggest a mechanism on insulin secretion by HNF4a. Taken together, the present study suggested that SOE might serve as immunosuppressive drug in PTDM. KCI Citation Count: 1