新鼻煎의 항알레르기 효과

• Published in: 동의생리병리학회지 Vol. 21; no. 6; pp. 1525 - 1533
• Main Authors: 김경렬(Kyung Yeol Kim), 김상태(Sang Tae Kim), 이종화(Jong Hwa Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.12.2007
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The discovery of drugs on the treatment of rhinitis and allergic disease is a very important subject in human heath. The Shinbijen has been used for centruries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from Shinbijen on OVA-mediated allergic reaction and studied its possible mechanism of action using fluorescenc microscopy and RT-PCR analysis. Shinbijen inhibited OVA-induced rhinitis, total cells in BFA and lymphocyte related to inflammation in mice. Shinbijen decreased immuno response, which activated by IL-4, COX-2 and iNOS expression. in tissue. Shinbijen reduced inflammatory molecule release from mice lung tissue and CD4/CD8 cells activated by cardiac blood. Shinbijen decreased OVA-induced IL-4 and iNOS levels in pulmonary alveoli. Our findings provide evidence that Shinbijen inhibits OVA-induced allergic reactions, and also demonstrate the involvement of inflammation and allergic disease in these effects. KCI Citation Count: 1