石菖蒲의 면역조절 및 항암효과

Methanol extracts of Acorus gramineus Solander(AGS) were found to exhibit immuno-regulatory action in BALB/c mice. Oral administration of AGS increased murine splenic T lymphocytes, especially TH and Tc/Ts subpopulations were increased significantly. Treatment of AGS exerted strong cytotoxicity agai...

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Published in동의생리병리학회지 Vol. 21; no. 4; pp. 869 - 873
Main Authors 오찬호(Chan Ho Oh), 김남석(Nam Seok Kim), 이규희(Kyu Hee Lee), 김태호(Tae Ho Kim), 배진범(Jin Bum Bae), 김순근(Sun Geun Kim), 전훈(Hoon Jeon), 임종필(Jong Phil Lim), 신태용(Tae Yong Shin), 이창현(Chang Hyun Lee), 정승일(Seung Il Jeong), 권진(Jin Kwon)
Format Journal Article
LanguageKorean
Published 한의병리학회 01.08.2007
Subjects
한의학
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ISSN1738-7698
2288-2529

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Summary:Methanol extracts of Acorus gramineus Solander(AGS) were found to exhibit immuno-regulatory action in BALB/c mice. Oral administration of AGS increased murine splenic T lymphocytes, especially TH and Tc/Ts subpopulations were increased significantly. Treatment of AGS exerted strong cytotoxicity against U937 and HL60 human leukemia cells. Also, AGS induced apoptosis of U937 leukemia cells in a dose dependent manner. Nitric oxide(NO) production and iNOS gene expression were also increased　in　AGS-treated RAW264.7 cells. Treatment of AGS increased the expression of p53 gene and decreased the expression of PCNA protein in cultured U937 cells. These data suggest that AGS are effective on the immuno-regulatory action and anti-cancer properties. KCI Citation Count: 7
Bibliography:G704-000534.2007.21.4.027
ISSN:1738-7698
2288-2529