Cisplatin에 의한 耳毒性에서 苓桂朮甘湯의 보호 효과

• Published in: 동의생리병리학회지 Vol. 26; no. 5; pp. 699 - 706
• Main Authors: 전호성(Ho Seong Jeon), 박래길(Rae Gil Park), 소홍섭(Hong Seob So), 정명수(Myong Soo Chong), 이수경(Su Kyung Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.10.2012
• Subjects: 한의학; cisplatin; ototoxicity; younggyechulgam-tang(?桂朮甘湯)
• ISSN: 1738-7698; 2288-2529

The water extract of Younggyechulgam-tang (YGCGT) has been traditionally used in treatment of tinnitus in Oriental Medicine. However, little is known about the mechanism by which YGCGT rescues ototoxicity. The purpose of the present study is to investigate the protective effect of YGCGT against cisplatin-induced toxicity in HEI-OC1 auditory cells, organotypic cultures of cochlear explants from three-day postnatal rats (P3). Pretreatment with YGCGT ameliorated apoptotic death induced by cisplatin in HEI-OC1 cells and organotypic cultures of Corti’s organ. YGCGT pretreatment also significantly suppressed cisplatin-induced increases in intracellular reactive oxygen species (ROS). Treatment with YGCGT resulted in an increased expression of HO-1 and Bcl-2. These results suggest that YGCGT induced HO-1 signaling pathway, which ultimately prevents free radical stresses from cisplatin and further contributes to protect auditory sensory hair cells from free radicals produced by cisplatin. KCI Citation Count: 0