SD계 흰쥐에 대한 太陰調胃湯의 급성 경구 독성 시험 연구

• Published in: 동의생리병리학회지 Vol. 22; no. 6; pp. 1439 - 1443
• Main Authors: 장문석(Mun Seog Chang), 심경준(Kyung Jun Shim), 김휴영(Hyu Young Kim), 박은화(Eun Hwa Park), 고은빛(Eun Bit Ko), 최봉재(Bong Jae Choi), 양웅모(Woong Mo Yang), 임형호(Hyung Ho Lim), 이명종(Myeong Jong Lee), 박성규(Seong Kyu Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.12.2008
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The objective of this study was to evaluate the acute toxicity of Taeumjowi-tang in rats. SPF Sprague-Dawley male and female rats were administered orally with Taeumjowi-tang extract of 2,500 mg/kg(low dosage group), and 5,000 mg/kg(high dosage group). We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. No dead animal and no significant changes of body weights were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, Taeumjowi-tang extract did not show any toxic effects, and oral LD50 value was over 5,000 mg/kg in SD rats. The objective of this study was to evaluate the acute toxicity of Taeumjowi-tang in rats. SPF Sprague-Dawley male and female rats were administered orally with Taeumjowi-tang extract of 2,500 mg/kg(low dosage group), and 5,000 mg/kg(high dosage group). We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. No dead animal and no significant changes of body weights were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, Taeumjowi-tang extract did not show any toxic effects, and oral LD50 value was over 5,000 mg/kg in SD rats. KCI Citation Count: 11