위암에서 Claudin-4와 E-cadherin 단백 발현 감소와 임상-병리학적 인자들과의 연관성

• Published in: Annals of surgical treatment and research Vol. 73; no. 3; pp. 221 - 226
• Main Authors: 이성민(Sung Min Lee), 이정효(Jung Hyo Lee), 김범규(Beom Gyu Kim), 김용석(Yong Seok Kim), 박용검(Yong Gum Park), 지경천(Kyung Chun Chi), 임현묵(Hyun Muk Lim), 김상준(Sang Jun Kim)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.09.2007
• Subjects: 일반외과학; 위암; Stomach cancer; E-cadherin; Claudin-4
• ISSN: 2288-6575; 2288-6796

Purpose: We examined the expressions of claudin-4 and E-cadherin, which are known as cell adhesion-associated proteins, in stomach cancer. The relationship of their expression with the clinicopathologic factors was examined to investigate the roles of these proteins in the invasion or metastasis of stomach adenocarcinoma. Methods: The expressions of claudin-4 and E-cadherin were examined in 73 cases of adenocarcinoma of the stomach by performing immunohistochemical staining. Results: The expressions of claudin-4 and E-cadherin in the stomach adenocarcinoma were both correlated with the histologic grade, the T-stage and nodal metastasis, respectively (P＜0.05). The expression of claudin-4 was significantly associated with the expression of E-cadherin. Conclusion: Our data suggests that claudin-4 and E-cadherin are involved in the processes of histologic differentiation, invasion and metastasis of stomach adenocarcinoma. (J Korean Surg Soc 2007;73:221-226) KCI Citation Count: 1