결직장암에서 COX-2발현의 임상적 의의

• Published in: Annals of surgical treatment and research Vol. 64; no. 1; pp. 39 - 43
• Main Authors: 장현록(Hyun Rok Jang), 양근호(Keun Ho Yang), 배병노(Byung Noe Bae), 김기환(Ki Hwan Kim), 한세환(Se Hwan Han), 김홍주(Hong Joo Kim), 김영덕(Young Duck Kim), 김홍용(Hong Yong Kim), 김정연(Joung Yeon Kim)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 2003
• Subjects: 일반외과학
• ISSN: 2288-6575; 2288-6796

Purpose: Epidemiologic studies have indicated that the use of nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase activity, reduce the risk of colorectal cancer. In addition, several studies have demonstrated the increased expression of cyclooxygenase-2 (COX-2) in human colorectal cancer tissues. However, the role of COX-2 in colorectal cancer has not been fully established. The aim of this study was to clarify the clinicopathologic significance of COX-2 expression in human colorectal cancer. Methods: We performed immunohistochemical straining for COX-2 expression in 124 human colorectal cancer specimens. COX-2 expression was then compared with clinicopathologic factors and survival outcomes. Results: COX-2 was expressed in the cytoplasm of the cancer cells. COX-2 expression was noted in 86.3% of the cancer patients and significantly correlated with the histologic type. The depth of invasion ,tumor size, lymph node metastasis and stage were not correlated with COX-2 expression. Multivariate analysis for the factors associated with survival showed that serum CEA, size, depth and lymph node involvement correlated with survival, but COX-2 expression had no correlation. Conclusion: These data suggest that COX-2 expression in primary lesion of colorectal cancer may not be a useful marker for evaluating prognosis. However, further studies are necessary for identification of the roles in colorectal carcinogenesis. (J Korean Surg Soc 2003;64:39-43) KCI Citation Count: 1