C형 및 S형 단백 결핍에 의한 혈관 질환

• Published in: Annals of surgical treatment and research Vol. 62; no. 2; pp. 181 - 186
• Main Authors: 조용필(Yong Pil Cho), 이덕희(Deok Hee Lee), 정승문(Seung Mun Jung), 장혁재(Hyuk Jai Jang), 김지수(Jee Soo Kim), 한명식(Myoung Sik Han)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.02.2002
• Subjects: 일반외과학; 과응고 상태; Hypercoagulable state; Vascular diseases; C형 및 S형 단백 결핍; Protein C and S deficiencies; 혈관질환
• ISSN: 2288-6575; 2288-6796

Purpose: There are a number of conditions that can lead to a hypercoagulable state, however, protein C and S deficiencies are frequently described as causes of the hypercoagulable states. The aim of this study was to evaluate the clinical features and prognosis of vascular diseases associated with protein C and/or S deficiencies and to determine an adequate treatment modality for such cases. Methods: We prospectively evaluated 7 cases with vascular disease caused by protein C and/or S deficiencies confirmed with serologic tests. Results: Four patients showed venous thrombosis, 1 peripheral arterial insufficiency, 1 cerebral venous thrombosis and peripheral arterial insufficiency, and 1 portal vein thrombosis. Surgical intervention was required in 5 patients. Full anticoagulation with heparin sodium followed by warfarin sodium was done in all patients. Conclusion: Protein C and S deficiencies may influence clinical management. Patients presenting with atypical vascular involvement without evidence of other risk factors should be evaluated for a hypercoagulable state. Once the diagnosis is made, patients should be treated with full anticoagulation. (J Korean Surg Soc 2002;62:181-186) KCI Citation Count: 2