위장관 간질성 종양의 면역화학적염색법을 이용한 재진단 및 새로운 등급체계의 임상적 유용성

• Published in: Annals of surgical treatment and research Vol. 64; no. 6; pp. 471 - 479
• Main Authors: 이채영(Chae Young Lee), 김진조(Jin Cho Kim), 김원우(Won Woo Kim), 진현민(Hyung Min Chin), 김욱(Wook Kim), 박조현(Cho Hyun Park), 전해명(Hae Myung Jeon), 박승만(Seung Man Park), 임근우(Keun Woo Lim), 박우배(Woo Bae Park), 김승남(Seung Nam Kim), 이교영(Gyo Young Lee), 박경신(Gyeong Sin Park), 송도영(Do Young Song), 주종호(Jong Ho Joo)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.06.2003
• Subjects: 일반외과학
• ISSN: 2288-6575; 2288-6796

Purpose: Paraffin-embedded tissue samples from the gastrointestinal tract, which had been diagnosed as tumors of a mesenchymal origin, were reviewed by an immunohistochemical staining method. The prognostic significances of the immunohistochemical subtypes and anatomical locations were also investigated. GIST, as a new grading system, was compared with the pre-existing system for its useful prognostic significance. Methods: 122 cases were evaluated and classified by immunohistochemical staining for KIT, CD34, actin, desmin, vimentin, S-100 protein and NSE. Results: Positivity for both KIT and CD34 of 92.6 and 73.8%, respectively, indicated that KIT was more effective for the diagnosis of GISTs. The stomach (62.3%) and small bowel (23.7%) were most common organs of GIST. There was no difference in the prognosis between these two organs. Immunophenotypically, the uncommitted, myoid, combined and neural types were 37.7, 23.7, 20.2 and 7%, respectively. There was no significant difference in the prognosis between these types. The old grading system showed no difference between the borderline and malignant groups (P=0.14), whereas, the new grading system showed a significant difference between the intermediate and high risk groups (P=0.01). Conclusion: KIT is more useful for the diagnosis of GOSTs. The immunophenotypical classification and anatomical location showed no prognostic significance in GISTs. Therefore, the new grading system might be more useful than older system. (J Korean Surg Soc 2003;64:471-479) KCI Citation Count: 1