갑상선 미세유두암에서 MMP-2, MMP-9과 HIF-1α 발현의 임상적 의의

• Published in: Annals of surgical treatment and research Vol. 78; no. 3; pp. 157 - 164
• Main Authors: 최재영(Jae Young Choi), 배자성(Ja Seong Bae), 김영애(Young Ae Kim), 장은덕(Eun Deok Chang), 조항주(Hang Joo Cho), 김기환(Ki Hwan Kim), 안창혁(Chang Hyeok Ahn), 박우찬(Woo Chan Park), 김정수(Jeong Soo Kim)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.03.2010
• Subjects: 일반외과학; MMP-2; 갑상선암; HIF-1α; Papillary microcarcinoma; MMP-9; 미세유두암; Thyroid carcinoma
• ISSN: 2288-6575; 2288-6796

Purpose: Papillary Thyroid Microcarcinoma (PTMC) is rapidly increasing due to increased interests in the public health care system and improvements in ultrasonographic instruments and fine-needle-aspiration technique. The aim of this study is to investigate relationships between clinicopathologic features and molecular markers of PTMC and to help in developing therapeutic strategies in PTMC. Methods: Tissue samples from patients with 38 PTMC and 21 benign thyroid tumors that were operated on from Jan. 2006 to Nov. 2008 were used to make microarrays and immunohistochemical staining for ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α were performed. Clinicopathologic features of each immunohistochemical staining group were analyzed retrospectively. Results: There is no immunohistochemistry staining in cases with benign thyroid lesions. The expression rate of ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α in PTMC group was 66%, 58%, 82%, 66%, 71% and 63%, respectively. Bilateral tumor was statistically significant (48.0% vs 7.7%, P=0.015) related to MMP-2(＋) PTMC group than in MMP-2(−) group. Bilateral tumor (44.4% vs 9.1%, P=0.060) and lymphovascular invasion (25.9% vs 0%, P=0.084) seemed to have greater relation to MMP-9(＋) PTMC group than to MMP-9(−) group, but there is no statistically significant difference. Bilateral tumor (50.0% vs 7.1%, P=0.012), lymph node metastasis (45.8% vs 0%, P=0.003) and lymphovascular invasion (29.2% vs 0%, P=0.033) were significantly related to HIF-1α(＋) PTMC group compared to HIF-1α(−) group. Conclusion: Our findings suggest that MMP-2, MMP-9 and HIF-1α expression could be used as a prognostic marker in PTMC. Larger studies are needed to assess its prognostic value in PTMC. KCI Citation Count: 1