대장암에서 CD31과 D2-40 발현에 의한 혈관성 및 림프관성 미세혈관 밀도 측정

• Published in: Annals of surgical treatment and research Vol. 73; no. 4; pp. 315 - 320
• Main Authors: 윤상인(Sang In Youn), 김범규(Beom Gyu Kim), 차성재(Seong Jae Cha), 박성준(Sung Jun Park), 장인택(In Taek Chang), 박성일(Sung Il Park), 이태진(Tae Jin Lee)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.10.2007
• Subjects: 일반외과학; CD31; Angiogenesis; Colon cancer; 대장암; 림프관 신생; 혈관신생; Lymphangiogenesis; D2-40
• ISSN: 2288-6575; 2288-6796

Purpose: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and D2-40 expressions as prognostic factors in colon cancer. Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer. Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003). Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer. (J Korean Surg Soc 2007;73:315-320) KCI Citation Count: 1