Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe

• Published in: Archives of pharmacal research Vol. 31; no. 4; pp. 415 - 418
• Main Authors: Kim, Ju Sin, Lee, Sa Im, Park, Hye Won, Yang, Jae Heon, Shin, Tae-Yong, Kim, Youn-Chul, Baek, Nam-In, Kim, Sung-Hoon, Choi, Sang Un, Kwon, Byoung-Mog, Leem, Kang-Hyun, Jung, Mun Yhung, Kim, Dae Keun
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한약학회 01.04.2008
• Subjects: Animals; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Catechols - chemistry; Catechols - isolation & purification; Catechols - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Desiccation; Dose-Response Relationship, Drug; Fatty Alcohols - chemistry; Fatty Alcohols - isolation & purification; Fatty Alcohols - pharmacology; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Rhizome; Zingiber officinale - chemistry; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-001-1172-y

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).