Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa
Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocoryno...
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| Published in | Archives of pharmacal research Vol. 30; no. 2; pp. 151 - 154 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
대한약학회
01.02.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 |
| DOI | 10.1007/BF02977687 |
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| Abstract | Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells. |
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| AbstractList | Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells. Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells. Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells. KCI Citation Count: 37 |
| Author | Lee, Jae Hyeok Park, Hee Wook Kim, Sung-Hoon Choi, Sang Un Jeon, Hoon Yun, Mi-Young Shin, Tae Yong Leem, Kang-Hyun Eun, Jae Soon Baek, Nam-In Kim, Dae Keun Yang, Jae Heon Lim, Jong Pil |
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| SubjectTerms | Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Survival - drug effects Corydalis - chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Isoquinolines - isolation & purification Isoquinolines - pharmacology Molecular Structure Neutrophils - cytology Plant Components, Aerial - chemistry Structure-Activity Relationship 약학 |
| Title | Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa |
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