Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa

• Published in: Archives of pharmacal research Vol. 30; no. 2; pp. 151 - 154
• Main Authors: Choi, Sang Un, Baek, Nam-In, Kim, Sung-Hoon, Yang, Jae Heon, Eun, Jae Soon, Shin, Tae Yong, Lim, Jong Pil, Lee, Jae Hyeok, Jeon, Hoon, Yun, Mi-Young, Leem, Kang-Hyun, Park, Hee Wook, Kim, Dae Keun
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한약학회 01.02.2007
• Subjects: Alkaloids - isolation & purification; Alkaloids - pharmacology; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Adhesion - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Corydalis - chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoquinolines - isolation & purification; Isoquinolines - pharmacology; Molecular Structure; Neutrophils - cytology; Plant Components, Aerial - chemistry; Structure-Activity Relationship; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02977687

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.