Preparation of Biodegradable PLGA Nanospheres Employing a Fast Solvent Evaporation Method

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) pp. 1043 - 1046
• Main Authors: 이상길, Guang Jin Choi, 장정윤, Byung Soo Kwon, Hea Eun Lee, Dong Hwan Kim, Ho Kyung Kang, Jae Seon Kang
• Format: Journal Article
• Language: English
• Published: 한국공업화학회 01.11.2007
• Subjects: 화학공학
• ISSN: 1226-086X; 1876-794X

The traditional W1/O/W2 emulsion method has a limit on the control of particle size to a nano-scale with high drug encapsulation efficiency (EE%). In the present study, we modified the solvent removal time and rate to develop an oral peptide drug delivery system using sCT as a model drug. We monitored the effect of the type of poly (vinyl alcohol) (PVA) within the W2 phase on the EE%. SEM images and particle size measurements revealed that the outer surfaces of representative nanosphere samples were very fine and even; the particle size was 383.2 ± 8.7 nm with a narrow size distribution (polydispersity index = 0.25 ± 0.004). The EE% increased depending on the solvent removal time and rate from 11.4 ± 1.3 to 28.8 ± 3.0 and 52.5 ± 6.5, compared to control nanospheres, respectively. The EE% of sCT was also enhanced by controlling the molecular weight of PVA within the W2 phase. KCI Citation Count: 12