Protective Effect of Crataegus pinnatifida and Cinnamomum cassia on Ethanol-induced Cytotoxicity and DNA Damage in HepG2 Cells

Plant extracts produced from branches of Crataegus pinnatifida and barks of Crataegus pinnatifida inhibited ethanol-induced cytotoxicity and DNA damage in liver cells. Furthermore, these two extracts inhibited the expression and activities of CYP2E1 enzyme. Cinnamomum cassia had a better effect on i...

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Bibliographic Details
Published inNatural product sciences Vol. 20; no. 4; pp. 237 - 242
Main Authors Nam Yee Kim, Eun Jeong Song, Moon Young Heo
Format Journal Article
LanguageEnglish
Published 한국생약학회 2014
Subjects
약학
Cinnamomum cassia
Crataegus pinnatifida
Ethanol
DNA damage
Plant extract
Cytotoxicity
Comet assay
Online AccessGet full text
ISSN1226-3907
2288-9027

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Summary:Plant extracts produced from branches of Crataegus pinnatifida and barks of Crataegus pinnatifida inhibited ethanol-induced cytotoxicity and DNA damage in liver cells. Furthermore, these two extracts inhibited the expression and activities of CYP2E1 enzyme. Cinnamomum cassia had a better effect on inhibition of DNA damage than Crataegus pinnatifida, as well as showed a high tendency to inhibit CYP2E1 expression and catalytic activities. It is considered that extracts produced from Crataegus pinnatifida or Cinnamomum cassia have an effect to reduce ethanol-induced cytotoxicity and DNA damage in liver cells. Therefore, we suggest to use Crataegus pinnatifida and Cinnamomum cassia and their ingredients as potential candidate substances to prevent and treat ethanol-induced cytotoxicity and genotoxicity in liver cells. KCI Citation Count: 0
Bibliography:G704-001403.2014.20.4.011
ISSN:1226-3907
2288-9027