양단탕 추출물의 항염증 효과에 대한 연구

• Published in: 동의생리병리학회지 Vol. 34; no. 5; pp. 238 - 244
• Main Authors: 최수련(Su Ryeon Choi), 황형서(Hyung Seo Hwang), 김태연(Tae Yeon Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2020
• Subjects: 한의학; NO; Anti-inflammatory; Inflammatory factor; Yangdan-tang (YD)(陽旦湯); PGE; PGE_2; Yangdan-tang (YD)
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2020.10.34.5.238

Yangdan-tang (YD) is recorded as a treatment to treat exterior-related fever illness in the Korean medicine. In this study, we examined the anti-inflammatory effects of YD, using YD water extract and lipopolysaccharide (LPS)-induced RAW 264.7 cells. First of all, we measured the amount of nitric oxide (NO) and prostaglandin E2 (PGE2), the products of inflammatory metabolism. Also, we measured enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 alpha (IL-1α), and interleukin 1 beta (IL-1β). YD suppressed the production of NO and PGE2 in a dose dependent manner and reduced the amount of protein and the mRNA expression of iNOS and COX-2. Also, YD reduced the mRNA expression of TNF-α, IL-6, IL-1α and IL-1β. In conclusion, YD decreased production of LPS-induced inflammatory factor, which could be a clinical basic subject for inflammatory diseases.