멜라토닌과 정신과 질환

• Published in: Sumyŏn--chŏngsin saengni Vol. 22; no. 1; pp. 5 - 10
• Main Author: 이진성(Jin-Seong Lee), 김성곤(Sung-Gon Kim), 김지훈(Ji-Hoon Kim), 정우영(Woo-Young Jung), 박지훈(Ji-Hoon Park)
• Format: Journal Article
• Language: Korean
• Published: 대한수면의학회 01.07.2015; The Korean Academy of Sleep Medicine
• Subjects: 정신과학; Autism; Melatonin; Alzheimer’s disease; 하루주기리듬; 우울증; 알츠하이머병; Depression; Bipolar disorder; 자폐증; Circadian rhythm; 멜라토닌; 양극성 기분장애
• ISSN: 1225-7354; 2713-8631
• DOI: 10.14401/KASMED.2015.22.1.5

The secretion of melatonin exhibits a circadian rhythm entrained with the sleep-wake cycle. An alteration of this secretory rhythm has been found in various psychiatric disorders. This review summarizes the regulation of melatonin and its relationship to the circadian rhythm, major depressive disorder, bipolar disorder, seasonal affective disorder, Alzheimer's disease and autism. The review also looks at the effect of melatonin and melatonin agonist on sleep and symptoms of depression, bipolar disorder and seasonal affective disorder. In Alzheimer's disease, the circadian rhythm alterations are associated with the change of melatonin levels and melatonin receptors. It has been reported that melatonin and melatonin synthetic enzyme levels decrease in autism spectrum disorder.