고욤 잎 추출물의 항산화 활성 및 적혈구 산화적 손상에 대한 보호 효과

This study was to evaluate the antioxidant properties of the leaf extracts of Diospyros lotus (DLE) on the chemical-induced free radical and rat red blood cell (RBC) oxidative damage in vitro. DLE were prepared by extracting with water. DLE showed the high antioxidant activities on the scavenging of...

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Published in동의생리병리학회지 Vol. 27; no. 5; pp. 631 - 636
Main Authors 김현수(Hyeon Soo Kim), 강현주(Hyun Ju Kang), 전인화(In Hwa Jeon), 목지예(Ji Ye Mok), 박용균(Young Kyun Park), 신준호(Jun Ho Shin), 김장호(Jang Ho Kim), 장선일(Seon Il Jang)
Format Journal Article
LanguageKorean
Published 한의병리학회 2013
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ISSN1738-7698
2288-2529
2283-2529
DOI10.15188/kjopp.2013.10.27.5.631

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Summary:This study was to evaluate the antioxidant properties of the leaf extracts of Diospyros lotus (DLE) on the chemical-induced free radical and rat red blood cell (RBC) oxidative damage in vitro. DLE were prepared by extracting with water. DLE showed the high antioxidant activities on the scavenging of 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)-induced radicals. An antioxidant activities of DLE was similar to the reference antioxidant butylated hydroxytoluene (BHT) and (${\pm}$)6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox). Reducing power of $1,000{\mu}g/mL$ DLE also was similar to the vitamin C. In RBC, oxidative hemolysis induced by the aqueous peroxyl radical generator (2,2'-Azobis (2-methylpropionamidine) dihydrochloride (AAPH)) were significantly suppressed by DLE in a dose-dependent manner. Furthermore, DLE prevented the depletion of cytosolic antioxidant glutathione in RBC damaged with AAPH. These results suggest that DLE may has value as natural product with its high quality antioxidant properties against oxidative stress.
Bibliography:KISTI1.1003/JNL.JAKO201301442489667
http://www.hantopic.com/kjopp/KJOPP.htm
G704-000534.2013.27.5.005
ISSN:1738-7698
2288-2529
2283-2529
DOI:10.15188/kjopp.2013.10.27.5.631