마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과

In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6,...

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Published in동의생리병리학회지 Vol. 19; no. 4; pp. 1027 - 1031
Main Authors 김용준(Young Jun Kim), 이정치(Jeong Chi Lee), 김홍용(Hong Yong Kim), 설광화(Guanghua Xie), 윤용갑(Yong Gab Yun), 장선일(Seon ll Jang)
Format Journal Article
LanguageKorean
Published 한의병리학회 2005
Subjects
한의학
Scutellaria Radix
DTH
HO-1
wogonin
Th1
Th2
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ISSN1738-7698
2288-2529
2283-2529

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Summary:In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6, IL-10 and $IFN-\gamma$ on DNFB-induced Th1 and Th2 cytokines in a concentration-dependent manner. Interestingly, this compound increased the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner The above results reveal that wogonin possesses anti-inflammatory, humoral and cellular immunomodulatory, and stress reducing activities on the DNFB-induced DTH in mice and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.
Bibliography:KISTI1.1003/JNL.JAKO200504840760220
G704-000534.2005.19.4.037
ISSN:1738-7698
2288-2529
2283-2529