곤달비 메탄올 추출물의 진통 효과

• Published in: 생약학회지 Vol. 44; no. 1; pp. 70 - 74
• Main Authors: 차동석(Dong Seok Cha), 전훈(Hoon Jeon)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2013
• Subjects: 약학; Ligularia stempcephala; Anti-nociception; Pain; Ligularia stenocephala
• ISSN: 0253-3073; 2288-9299

Ligularia stenocephala has been widely used as a traditional medicine for the treatment of lots of diseases such as asthma, arthritis, and jaundice. In this study, we evaluated the anti-nocicepitve activities of methanolic extract of L. stenocephala (MLS) using various pain models including thermal nociception as well as chemical nociception methods. MLS showed significant increase in latency time in the tail immersion test and hot-plate test. In addition, the number of acetic acid-induced abdominal constrictions was decreased by MLS. MLS also attenuated paw licking time in the formalin test. The combination test using naloxone revealed that the anti-nociceptive properties of MLS was not associated with opioid receptor activation. The present results demonstrate that MLS may possibly used as valuable analgesic agent for the treatment of nociceptive pain.