SD계 흰쥐에 대한 마황 추출물의 급성 경구투여 독성 시험 연구

• Published in: 동의생리병리학회지 Vol. 22; no. 4; pp. 762 - 765
• Main Authors: 장문석(Mun Seog Chang), 심경준(Kyung Jun Shim), 오지훈(Ji Hoon Oh), 윤지원(Ji Won Yoon), 최문정(Moon Jung Choi), 김도림(Do Rim Kim), 양웅모(Woong Mo Yang), 임형호(Hyung Ho Lim), 이명종(Myeong Jong Lee), 박성규(Seong Kyu Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2008
• Subjects: 한의학; LD50; oral; Ephedrae herba(Ma-huang); rat; acute toxicity
• ISSN: 1738-7698; 2288-2529; 2283-2529

Ephedrae herba(Ma-huang) has been used to treat respiratory conditions for over 5,000 years. The early 1990s, the herbal ephedra and other products containing ephedrine began to be promoted as weight loss aids in United States. The objective of this study was to evaluate the acute toxicity of hebal ephedra in rats. SPF Sprague-Dawley male and female rats were administered orally with herbal ephedra extract of 2,500 mg/kg(low dosage group), and 5,000 mg/kg(high dosage group). We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. No dead animal and no significant changes of body weights were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, herbal ephedra extract did not show any toxic effects and oral LD50 value was over 5,000 mg/kg in SD rats.