건지황의 급성코카인 투여에 의한 ERK, CREB 인산화에 미치는 효과

• Published in: 동의생리병리학회지 Vol. 26; no. 3; pp. 281 - 286
• Main Authors: 권기원(Ki Won Kwon), 장은영(Eun Young Jang), 임채광(Chae Kwang Im), 양재하(Chae Ha Yang), 김광중(Kwang Joong Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2012
• Subjects: 한의학; Rehmannia glutinosa; CREB; nucleus accumbens; acute cocaine; striatum; ERK
• ISSN: 1738-7698; 2288-2529; 2283-2529

The present study was designed to investigate the effect of Rehmannia glutinosa on phosphorylation of extracellular signal-regulated kinase(ERK) and cAMP response element-binding protein(CREB) in the acute cocaine-treated rats. Rats orally received vehicle or extract of Rehmannia glutinosa 1 h prior to saline (1 ml/kg, i.p.) or cocaine hydrochloride (20 mg/kg, i.p.) treatment. Rats were sacrificed 15 min after a single intraperitoneal injection of saline or cocaine. Rehmannia glutinosa at dose of 50 mg/kg significantly decreased phosphorylation of ERK, CREB and Elk-1 in the nucleus accumbens and striatum of the cocaine-treated rat brain by immunocytochemistry. These results suggest that Rehmannia glutinosa may contribute to the effects of cocaine on gene expression and on behaviors.