Ferric Chloride로 유도된 렛트 경동맥 손상 및 혈전에 대한 수용성 엉겅퀴 잎 추출물의 혈행 개선 효과

The present study has been undertaken to investigate the effect of the extract of Cirsium japonicum var. ussuriense leaves (CLE) on blood circulation in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. $FeCl_3$ treatment seriously damaged the carotid artery such as th...

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Bibliographic Details
Published in생약학회지 Vol. 44; no. 2; pp. 131 - 137
Main Authors 강현주(Hyun Ju Kang), 김현수(Hyeon Soo Kim), 전인화(In Hwa Jeon), 목지예(Ji Ye Mok), 정승일(Seung Il Jeong), 심재석(Jae Suk Shim), 장선일(Seon Il Jang)
Format Journal Article
LanguageKorean
Published 한국생약학회 2013
Subjects
약학
Blood circulation
Cirsium japonicum var. ussuriense
Ameliorative effect
Anti-inflammation
Leaf extract
Cirsium japonicum var
ussuriense
Online AccessGet full text
ISSN0253-3073
2288-9299

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Summary:The present study has been undertaken to investigate the effect of the extract of Cirsium japonicum var. ussuriense leaves (CLE) on blood circulation in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. $FeCl_3$ treatment seriously damaged the carotid artery such as the walls of the artery, blood flow and inflammation. However, CLE administration has ameliorated blood circulation and suppressed vessel inflammation. CLE administration also has ameliorated the $FeCl_3$-induced artery tissue damage. Furthermore, CLE significantly suppressed the expression of adhesion molecules. These results suggest that CLE ameliorate blood circulation through suppress inflammatory mediator and adhesion molecule production.
Bibliography:KISTI1.1003/JNL.JAKO201319953222200
G704-000753.2013.44.2.011
ISSN:0253-3073
2288-9299